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Cytosolic Iron-Sulfur Cluster Assembly (CIA) System: Factors, Mechanism, and Relevance to Cellular Iron Regulation*

机译：胞质铁硫簇组装（CIA）系统：因素，机理和与细胞铁调节的相关性*

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FeS cluster biogenesis is an essential process in virtually all forms of life. Complex protein machineries that are conserved from bacteria through higher eukaryotes facilitate assembly of the FeS cofactor in proteins. In the last several years, significant strides have been made in our understanding of FeS cluster assembly and the functional overlap of this process with cellular iron homeostasis. This minireview summarizes the present understanding of the cytosolic iron-sulfur cluster assembly (CIA) system in eukaryotes, with a focus on information gained from studies in budding yeast and mammalian systems.

机译：FeS簇生物发生实际上是所有生命形式中必不可少的过程。通过高级真核生物从细菌中保守的复杂蛋白质机制有助于蛋白质中FeS辅因子的组装。在过去的几年中，在我们对FeS簇组装以及该过程与细胞铁稳态的功能重叠方面的理解上已取得了长足的进步。这份简短的综述总结了对真核生物中胞质铁硫簇装配（CIA）系统的当前理解，重点是从酵母和哺乳动物系统萌芽中获得的信息。

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Sharma, Anil K.; Pallesen, Leif J.; Spang, Robert J.; Walden, William E.;
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年度 2010
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1. Identification of a Key Intermediate of Relevance to Iron-Sulfur Cluster Biosynthesis. Mechanism of Cluster Assembly and Implications for Protein Folding [J] . Kshama Natarajan, J. A. Cowan Journal of the American Chemical Society . 1997,第17期

机译：鉴定与铁硫团簇生物合成有关的关键中间体。簇组装的机理及其对蛋白质折叠的影响
2. CIAO3 protein forms a stable ternary complex with two key players of the human cytosolic iron-sulfur cluster assembly machinery [J] . Journal of biological inorganic chemistry: JBIC: a publication of the Society of Biological Inorganic Chemistry . 2020,第3期

机译：CiaO3蛋白形成稳定的三元复合体，与人细胞溶质铁 - 硫集合机械的两个关键球员
3. Minimal cytosolic iron-sulfur cluster assembly machinery of Giardia intestinalis is partially associated with mitosomes [J] . Pyrih Jan, Pyrihova Eva, Kolisko Martin, Molecular Microbiology . 2016,第4期

机译：贾第鞭毛虫的最小胞质铁硫簇组装机制与线粒体部分相关
4. EXPRESSION OF IRON-SULFUR CLUSTER ASSEMBLY FACTOR, IscS, FROM GREEN SULFUR BACTERIUM CHLOROBIUM TEPIDUM IN ESCHERICHIA COLI [C] . Hiroki Aral, Kazuhito Inoue International Congress of Photosynthesis . 2005

机译：铁 - 硫簇组装因子，ISCs的表达，从青春期大肠杆菌中绿色硫磺氯橡胶
5. Dissecting the contributions of proteolysis, iron-sulfur cluster assembly, and transcriptional repression on the regulation of the Escherichia coli transcription factor FNR. [D] . Mettert, Erin Leigh. 2007

机译：剖析蛋白水解，铁硫簇组装和转录抑制对大肠杆菌转录因子FNR调控的贡献。
6. Cytosolic Iron-Sulfur Cluster Assembly (CIA) System: Factors Mechanism and Relevance to Cellular Iron Regulation [O] . Anil K. Sharma, Leif J. Pallesen, Robert J. Spang, 2010

机译：胞质铁硫簇组装（CIA）系统：因素机理和与细胞铁调节的相关性
7. The Association of the Xeroderma Pigmentosum Group D DNA Helicase (XPD) with Transcription Factor IIH Is Regulated by the Cytosolic Iron-Sulfur Cluster Assembly Pathway [O] . Ajay A. Vashisht, Clarissa C. Yu, Tanu Sharma, 2015

机译：具有转录因子IIH的Xeroderma Pigmentos组D DNA螺旋酶（XPD）的关联由胞岩铁 - 硫簇组装途径调节

Cytosolic Iron-Sulfur Cluster Assembly (CIA) System: Factors, Mechanism, and Relevance to Cellular Iron Regulation*

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